TYRPHOSTIN AG 18
tyrphostin 23
CAS: 118409-57-7
Molecular Formula: C10H6N2O2
TYRPHOSTIN AG 18 - Names and Identifiers
| Name | tyrphostin 23 |
| Synonyms | AG 18 RG-50810 tyrphostin 23 TYRPHOSTIN 23 TYRPHOSTIN A23 TYRPHOSTIN AG 18 TYRPHOSTIN RG 50858 RARECHEM AL BX 0069 ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMONITRILE |
| CAS | 118409-57-7 |
| InChI | InChI=1/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H |
TYRPHOSTIN AG 18 - Physico-chemical Properties
| Molecular Formula | C10H6N2O2 |
| Molar Mass | 186.17 |
| Density | 1.428±0.06 g/cm3(Predicted) |
| Melting Point | 225°C |
| Boling Point | 421.1±45.0 °C(Predicted) |
| Flash Point | 208.5°C |
| Solubility | DMSO 37 mg/mL Water <1 mg/mL Ethanol 37 mg/mL |
| Vapor Presure | 1.09E-07mmHg at 25°C |
| Appearance | Yellow to Green Powder |
| Color | Yellow |
| Maximum wavelength(λmax) | ['464nm(DMSO)(lit.)'] |
| pKa | 7.26±0.18(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Store in refrigerator |
| Refractive Index | 1.696 |
| MDL | MFCD00133899 |
| Use | Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils. |
| In vitro study | AG 18 inhibited EGFR and IR, and K I was 11 μm and 12 mM, respectively. AG 18 acted on A431 cells to inhibit EGFR autophosphorylation induced by EGF, and the IC50 was 15 μm. AG 18 (10 μm) inhibited the proliferation of GH3 cells induced by EGF. AG 18(10 μm) now inhibits cell proliferation induced by 10 nM and 1 μm Ghrelin. AG 18(10 μm) inhibited Ghrelin-stimulated increase in ERK1/2 phosphorylation in GH3 cells. AG18 acts on primary cultured astrocytes, inhibits volume-sensitive [AG 18 (300μm) acts on A549 epithelial cells, and inhibits TPA-induced stimulation of ICAM-1 expression in a dose-dependent manner. AG 18(300 μm) also inhibited TPA-stimulated NF-kappaB DNA-protein binding and ICAM-1 promoter activity in A549 epithelial cells. AG 18(100 μm) inhibits TNF-alpha-and TPA-stimulated IKK activity in A549 epithelial cells. AG 18(10 μm) acts on the carotid artery, reducing the potency of 5-HT by a factor of 4 and reducing the maximum contraction of 5-HT. AG 18(10 μm) transferred 2-fold KCl-induced contraction and produced maximal significant inhibition. |
TYRPHOSTIN AG 18 - Risk and Safety
| WGK Germany | 3 |
TYRPHOSTIN AG 18 - Introduction
Tyrphostin 23
Last Update：2022-10-16 17:12:29
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